Calcium Renal Stone in Relation to Salivary and Urinary Constituents

Shaimaa Kh. Yaser, Mohammed S. Al-Casey, Ali Y. Majid


Background: Renal stone which is actually renal calculi commonly termed as kidney stone may contribute to the development of chronic kidney disease and its incidence is rising rapidly; this study conducted to investigate the ability of using saliva as an indica- tor of susceptibility to calcium renal stone formation by investigating some salivary and urinary constituents among patients with idiopathic calcium renal stone then comparing the results with healthy looking subjects.

Materials and Methods: The study group selected of thirty patients with idiopathic calcium renal stone with an age range (25-30) year’s old and 30 gender and age matched healthy looking subjects selected as control. Stimulated salivary samples in addition to fasting second morning urinary samples collected then chemically analyzed to determine the concentrations of salivary and urinary calcium, phosphate, magnesium in addition to urinary creatinine.

RESULTS High significant elevation in the concentration of salivary phosphate with high significant reduction in salivary magnesium concentration recorded within study group compared control one while for salivary calcium concentration, found higher in study group but with no significant difference between them. The calcium stone formers found to have no hypercalciuria but they had higher level of urinary phosphate/creatinine ratio with high significant difference compared with the non stone formers while they had a high significant reduction for urinary magnesium/creatinine ratio compared with the control group.

Conclusion: Saliva may provide an investigative tool for calcium renal stone disease by using the salivary magnesium concentration as an indicator of susceptibility to calcium renal stone formation for both males and females.

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