The Role of Infliximab Local Injection on Orthodontic Tooth Movement in Experimentally Induced Diabetic Rabbits”

Abstract

Introduction: Orthodontic treatment in diabetic patients is usually associated with periodontal disease and bone loss. Proinflammatory
tumor necrosis factor-alpha (TNF-á) level increases in the periodontal tissue during orthodontic treatment. The aim of this
study was to investigate the effect of infliximab (tumor necrosis factor-á antagonist) local injection on orthodontic tooth movement
in diabetic rabbits.
Methods: diabetes was induced in 22 male adult rabbit using Alloxan intravenous injection(100mg/kg). The level of blood glucose
was controlled using subcutaneous insulin injection(0.5 IU/Kg Body weight). An orthodontic appliance was placed on the upper
central incisors of all rabbits for 18 days to create a space between the two teeth. The rabbits were divided into two equal groups,
the experimental group received 5mg/kg subperiosteal injection of tumor necrosis factor-alpha antagonist (infliximab)in the labial
side of the upper central incisors in three time intervals (0,7,13 days )of the study period. The control group received equivalent
volume of normal saline in the same location and same time intervals as experimental group. Clinical measurement of the created
space were done in(5, 9,13, 18 )days of the studying period .
Results: There was a significantly smaller rate of tooth movement in experimental group than control group represented by smaller
spaces created.
Conclusions: local injection of infliximab decrease the movement of the tooth during orthodontic treatment in experimentally
induced diabetic rabbits.