The Beneficial Use of Nigella Sativa Powder in the Healing of Different Portions of Extracted Tooth Socket: In Vivo Study

Abstract

Back ground: Nigella sativa is so beneficial due to it’s content of over a hundred components such as aromatic oils, trace elements, vitamins and enzymes. It contains 58% of essential fatty acids including omega 6 and omega 3. These are necessary for the forming of Prostaglandin E1 which balances and strengthens the immune system giving it the power to prevent infections and allergies and control chronic illnesses. Blackseed oil also contains about 0.5 - 1.5% volatile oils including nigellone and thymochinone which are responsible for its anti-histamine, anti-oxidant, anti-infective and broncho-dilating effect.

Aim of the study: To evaluate the effect of Nigella sativa (powder and oil) on the healing process in different portions of rabbit socket by histomorphometric analysis of bone architecture parameters.

Materials and Methods: The sample of the study consist of twenty rabbits, extract their upper two central incisors under general anesthesia. The left side filled once with Nigella sativa powder and once with Nigella sativa oil material, and the right side left for normal healing as a control group. The two sockets were sutured. The results were studied in intervals period 2 and 6 weeks, histologically and then assayed for histomorphometic analysis for trabecular width, trabecular number and the trabecular separa- tion Marrow space star volume analysis (V*m), Osteoblast, osteocyte, and blood vessels number, in coronal, middle and apical portions of extracted tooth socket. These parameters are derived from microscopic two dimension image measurements analyzer software program.

Results: Histomorphometric analysis for variables of trabeculae width (thickness of trabeculae), trabecular separation and cortical thickness in three studied groups for coronal, middle and apical portions of socket showed significant differences in NgS powder and oil groups in comparison to control. Bone marrow star volume showed a significant variation between NgS powder and NgS oil in comparison to control, also bone marrow star volume showed decrease in it’s value with increment in healing period in all groups. Trabecular number and width shows to be higher in NgS powder group in all portions of the socket in comparisum to control and NgS oil groups at 2 and 6 weeks duration. Blood vessels’ number shows to be higher in middle portion in NgS powder group at 2 and 6 weeks duration in comparisum to NgS oil and control groups.

Conclusion: Nigella sativa powder suggest to be more effective and enhancer in acceleration of bone formation than oil.